Rate of transfusion-associated adverse reactions by type U.S. 2019

In 2019, there were an estimated 293.7 blood transfusion-associated adverse reactions in the United States that required any diagnostic or therapeutic intervention per 100,000 components transfused. This graph shows the estimated rate of blood transfusion-associated adverse reactions in the United States in 2017 and 2019, by type, per 100,000 components transfused.

Rate of blood transfusion-associated adverse reactions in the United States in 2017 and 2019, by type (per 100,000 components transfused)

Characteristic	2017	2019
Total number of reactions that required any diagnostic or therapeutic intervention*	281.8	293.7
Febrile, nonhemolytic transfusion reaction	120.5	119.1
Mild to moderate allergic reactions	88.4	81.5
Delayed serologic transfusion reaction	18.6	19
Transfusion-associated circulatory overload	11.7	13.4
Hypotensive transfusion reaction	9.1	8.7
Transfusion-associated dyspnea	6.5	7
Delayed hemolytic transfusion reaction	4.8	4.1
Severe allergic reactions	2.5	2.7
Transfusion-related acute lung injury	1.5	1.5
Acute hemolytic transfusion reaction (other antibodies)	0.84	1
Posttransfusion purpura	3.7	0.63
Transfusion-transmitted bacterial infection (previously asked as posttransfusion sepsis)	0.23	0.35
Acute hemolytic transfusion reaction (ABO)	0.21	0.33
Transfusion-transmitted parasitic infection	0.07	0.02
Transfusion-transmitted viral infection	0.04	0.02
Reactions that were life threatening, requiring major medical intervention**	4.7	2.7

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Release date

August 2021

More information

Region

United States

Survey time period

2017 and 2019

Method of interview

Online omnibus survey

Supplementary notes

Data is from the National Blood Collection and Utilization Survey (NBCUS).
The 2019 NBCUS "was distributed to all US blood collection centers, all hospitals performing ≥1000 surgeries annually, and a 40% random sample of hospitals performing 100–999 surgeries annually. The response rates for the 2019 NBCUS were 94.3%(50/53) for community-based blood collection facilities, 84% (76/90) for hospital-based blood collection facilities, and 76% (2140/2808) for transfusing hospitals."
* Diagnostic tests were defined as “any test to confirm a reaction occurred” and therapeutic intervention was defined as “intervention to treat a reaction (e.g., vasopressors, intubation, transfer to intensive care to prevent impairment, permanent damage, or death).
** For example, vasopressors, blood pressure support, intubation, or transfer to the intensive care unit.

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