Clinical trials

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Statista dossier about clinical research

This dossier presents key facts and figures about clinical trials worldwide, with a focus on the United States. Clinical trials are also known as Phase I to IV within the research, development, and approval process for new drugs, medical devices, or procedures. This document gives you an overview about health R&D in general, number of clinical studies, success rates, costs, and many more.

Table of contents

  • 1. R&D overview

    • Total global pharmaceutical R&D spending 2012-2026

    • Industry sectors - expenditure on research and development 2015-2019

    • Top pharmaceutical R&D projects based on net present value June 2020

    • Research and development expenditure: U.S. pharmaceutical industry 1995-2019

    • Research and development in European pharmaceutical industry by country 2018

    • Total clinical research funding by National Institutes for Health 2013-2020

  • 2. Top R&D companies

    • Global top pharmaceutical companies based on R&D spending 2026

    • Top 50 global pharmaceutical and biotech companies by R&D intensity in 2019

    • Top pharmaceutical companies in R&D spending growth 2019

    • Leading global contract research organizations based on revenue 2019

    • Roche: participation of patients in clinical trials 2009-2017

  • 3. Clinical studies

    • Increase in clinical trials' complexity 2001-2015

    • Clinical trial success rates by therapeutic area 2020

    • Number of registered clinical studies by location worldwide 2021

    • Percent of registered clinical studies worldwide by location 2021

    • Share of recruiting clinical studies worldwide by location 2021

    • Total number of registered clinical studies worldwide since 2000

    • Total number of registered clinical studies with posted results worldwide 2008-2021

  • 4. Participation

    • Top clinical trial participant countries worldwide 2015-19, by share

    • Clinical trial participants U.S. vs. rest of world by therapy area 2015-2019

    • Clinical trial participants gender share worldwide 2015-19, by geographic location

    • Clinical trial participants ethnicity share worldwide 2015-19, by geographic location

  • 5. Costs and market

    • Pharmaceuticals: cost of drug development in the U.S. since 1975

    • R&D expenditure of new therapeutic drugs 2009-2018

    • Estimated clinical trial cost per patient by therapeutic class 2015-2017

    • Estimated clinical trial cost per drug by therapeutic class 2015-2017

    • Clinical CRO market size worldwide 2015-2024

    • Global pharma CRO market size 2015-2024, by pre-clinical, clinical and discovery

    • Size of total U.S. clinical trial supplies market 2016-2025

  • 6. Approvals, launches, setbacks

    • Pharmaceutical industry - number of new substances 1998-2019

    • Number of novel drugs approved annually by CDER 2008-2020

    • Key measurements of U.S. CDER drug approvals in 2020

    • FDA first premarket approvals for medtech products granted 2005-2019

    • Projection of top 2021 pharma and biotech launches by revenue 2026

    • Number of unsuccessful Alzheimer’s drugs in development in the U.S. 1998-2017

  • 7. COVID-19

    • Top companies by COVID-19 treatment vaccines in development March 2021

    • Number of COVID-19 treatment vaccines in development worldwide by phase 2021

    • Number of COVID-19 treatment vaccine trials worldwide by phase March 2021

    • Number of COVID-19 treatment vaccine trials worldwide by type March 2021

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