Vaccination

How Vaccines Helped All But Eradicate Diseases

Vaccines have been around for a long time and the first one is generally credited to Edward Jenner, an English doctor who injected pus from a cowpox pustule into an incision on an eight-year old's arm on May 14, 1796. The boy then proved immune to smallpox, one of the deadliest diseases at that time.

Data from the Centers for Disease Control and Prevention shows just how effective vaccines have been in all but eradicating major diseases in the United States. Some diseases have in fact been eradicated with no new cases of polio or smallpox in decades in the United States compared to a 20th cenrury average of more than 10,000 cases per year. And even though progress in eradicating measles has stalled in recent years (due in part to growing vaccine skepticism), its morbidity is nowhere near the annual case load seen in the 20th century, when half a million people were infected in an average year. Its prevalence has fallen by more than 99 percent due to vaccinations, along with a whole host of other diseases such as pertussis (whooping cough), mumps and rubella.

Description

This chart compares annual 20th century morbidity for selected vaccine-preventable diseases to current (2023) morbidity in the U.S.

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Reported cases of select vaccine-preventable diseases in the U.S. from 1980 to 2023, by disease
Reported cases of vaccine-preventable diseases worldwide from 1980 to 2025, by disease
Average number of annual smallpox deaths per million inhabitants in England during the various stages of vaccination implementation between 1700 and 1898
Number of smallpox cases recorded in the United States from 1900 to 1952
Annual number of cases of select infectious diseases in the U.S. before and after the development and use of vaccinations as of 2023
Reported number of smallpox cases globally between 1920 and 1980

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