U.S. pharmacies ranked by prescription drugs market share 2020

The top U.S. pharmacy in 2020 by market share based on prescription drug revenue was CVS Health Corporation, followed by Walgreens Boots Alliance. CVS Health held nearly 25 percent of the prescription drug market revenue at that time. A significant increase in market share was reported for Cigna achieved through the acquisition of pharmacy benefit manager Express Scripts in August 2018. Before that, Cigna was mainly active in the insurance business and related products and services.

CVS pharmacies

The CVS Health Corporation is a health service company with location all over the United States, Puerto Rico and Brazil. CVS health comprises pharmacies, clinics and retail locations. According to recent estimates the number of CVS pharmacies has increased dramatically since 2005. In 2020, CVS Health was also one of the two top specialty drug pharmacies in the United States based on market share.

Pharmaceutical and pharmacy market

The U.S. has the largest single share of global pharmaceutical market revenues. The total number of prescription drugs dispensed in the U.S. has declined in the last years, reaching around 4.2 billion medical prescriptions in 2019. Prescription drug expenditures have been increasing in value while the share related to total U.S. health expenditures has remained stable in recent years. On the other hand, the pharmacy market recently saw some significant changes, especially with the growing impact of online pharmacies (mail-order pharmacies) worldwide.

Top U.S. pharmacies ranked by prescription drugs market share in 2020

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Release date

March 2021


United States

Survey time period


Supplementary notes

Market shares reflect calendar year 2020, which may not correspond to fiscal year reporting.
* Retail Pharmacy: 15.1%; Pharmacy Services: 9.7 %.
** In 2018, Cigna acquired Express Scripts.

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Statistics on "CVS Health"

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