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Leading drug store chains in the United States 2016, based on Rx sales

In terms of Rx sales, CVS Health and Walgreens were the two leading drug stores chains in the United States in 2016.

Prescriptions in the United States

In 2018, some 4.19 billion retail prescriptions were filled in the United States. The number of retail prescriptions filled on an annual basis is expected to increase to 4.57 billion by 2024. For CVS, pharmacy services accounted for the largest share of the company’s revenue. Over the last several decades the consumer price index for prescription drugs in the United States has increased at an alarming rate, from 72.5 in 1980 to 522.1 in 2018.

CVS Health and Target

In December 2015, Target and CVS Health announced the acquisition by CVS of all of Target’s pharmacy and clinic business. Subsequently, all of the pharmacy sections in Target stores were replaced with CVS Health signage and CVS branded products. This could explain the sudden jump in CVS’s share of retail prescriptions filled in the United States, from 23.45 percent to 30.1 percent between 2015 and 2016.

Leading 20 drug store chains in the United States in 2016, based on Rx sales

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Release date

April 2017


United States

Survey time period


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Statistics on "Drug store/pharmacy market in the U.S."

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