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Blood transfusion-associated adverse reactions in the U.S. in 2017 and 2019

Number of blood transfusion-associated adverse reactions in the United States in 2017 and 2019, by type

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Release date

August 2021


United States

Survey time period

2017 and 2019

Method of interview

Online omnibus survey

Supplementary notes

Data is from the National Blood Collection and Utilization Survey (NBCUS).
The 2019 NBCUS "was distributed to all US blood collection centers, all hospitals performing ≥1000 surgeries annually, and a 40% random sample of hospitals performing 100–999 surgeries annually. The response rates for the 2019 NBCUS were 94.3%(50/53) for community-based blood collection facilities, 84% (76/90) for hospital-based blood collection facilities, and 76% (2140/2808) for transfusing hospitals."
* Diagnostic tests were defined as “any test to confirm a reaction occurred” and therapeutic intervention was defined as “intervention to treat a reaction (e.g., vasopressors, intubation, transfer to intensive care to prevent impairment, permanent damage, or death).
** For example, vasopressors, blood pressure support, intubation, or transfer to the intensive care unit.

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