Deadliest pandemics in history worldwide

This statistic presents the number of deaths from the deadliest pandemics in history worldwide, in millions. From around 10,000 BC to 1979, smallpox claimed the lives of over 300 million people, making it the deadliest pandemic in human history.

Number of deaths from the deadliest pandemics in history worldwide

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Release date

August 2011



Survey time period

as of 2011

Supplementary notes

* high estimate.
Although these diseases do not have figures for the total number of attributable deaths, they continue to cause significant loss around the world:
Malaria (1600-present): 781,000 deaths per year.
Tuberculosis (700 BC-present): 2 million deaths per year.
Yellow fever (1600 BC-present): 30,000 deaths per year.

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