World pharmaceutical sales by region forecast 2025

Total pharmaceutical sales numbers in North America are projected to amount to some 706 billion U.S. dollars in 2025, making it the regional submarket with the highest global pharma sales by far.

Pharmaceutical spending and product revenue

In 2025, the United States is projected to spend between 605 and 635 billion U.S. dollars on medicine, making it the country with the highest pharmaceutical spending by far. China, which is estimated to be in second place, has a maximum projected expenditure estimate of 200 billion U.S. dollars for that year. The top pharmaceutical products for 2026 are expected to be Keytruda, Opdivo, and Eliquis, respectively. Keytruda by Merck & Co is forecast to generate almost 27 billion U.S. dollars in revenue in 2026.

Chemical and biological substances

Given that U.S. pharmaceutical expenditures are some of the highest in the world, it comes to no surprise that the United States produces a large volume of new chemical or biological entities each year. Between 2016 and 2020, American companies introduced a total of 138 new chemical or biological substances. Within the same period, Europe introduced 64 new entities.