World pharmaceutical sales by region forecast 2028
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Total pharmaceutical sales numbers in North America are projected to amount to around 853 billion U.S. dollars in 2028, making it the regional submarket with the highest global pharma sales.
Pharmaceutical spending and product revenue
In 2026, the United States is projected to spend between 685 and 715 billion U.S. dollars on medicine, making it the country with the highest pharmaceutical spending by far. China, which is estimated to be in second place, has a maximum projected expenditure estimate of 190 billion U.S. dollars for that year. The top pharmaceutical product for 2026 is expected to be Keytruda. Keytruda by Merck & Co is forecast to generate almost 27 billion U.S. dollars in revenue in 2026.
Chemical and biological substances
Given that U.S. pharmaceutical R&D expenditures are the highest in the world, it comes to no surprise that the United States produces the largest volume of new chemical or biological entities each year. Between 2019 and 2023, American companies introduced a total of 148 new chemical or biological substances. Within the same period, Europe introduced 81 new entities.
