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Medical biotechnology - Statistics & Facts

In general, biotechnology is defined as the use of biological systems or living organisms for the development of its products. The same is true for biopharmaceuticals, also known as biotech drugs, or biologics. Biotech drugs are also called large molecule drugs because they have a large, complex molecular structure and are more difficult and expensive to produce. In contrast to that, small molecule drugs are chemical-pharmaceutical products with less complexity. While these ‘classic’ pharmaceuticals still make up around 90 percent of all drugs available on the global market, biopharmaceuticals already generate nearly one third of global drug sales. Several smaller biotech companies, previously only known to industry insiders, have become apparent lately through their involvement in the search for a COVID-19 vaccine.

Biotech’s regional concentration

The key regions for the biotech industry are the United States and Europe where most of the nearly 290 billion U.S. dollars of global biotech drug sales are generated. California (Bay Area, L.A., San Diego) and the U.S. Northeast (Boston area, New York, New Jersey) are global leading hubs based on the concentration of life sciences/biotech knowledge. Many of the world’s largest biotech companies originate from these areas as well as many of the most promising startups.

Top companies Amgen and Roche

Amgen, based in Thousand Oaks, California, is the world's largest pure-play biopharmaceutical company by revenue. However, since the acquisition of U.S.-based Genentech in 2009, Swiss pharmaceutical company Roche has the highest biotech revenues worldwide. It is not easy to define a company as biotech or classic pharma since most of the pharma giants already have a mixed portfolio of products with biotech-derived drugs making up an increasing share of total revenues.

Biologics already dominate

When it comes to top-selling drugs, biologics already have a predominant position compared to classic, small molecule drugs. Most of the world’s leading drugs based on revenue are biotech-derived. Illinois-based company AbbVie is the manufacturer of the currently best-selling biotech drug worldwide - Humira. Another biopharmaceutical, Merck’s cancer drug Keytruda, is expected to take over the leading position and to become the most-revenue-generating drug ever by 2026. Oncology is extremely prominent among biotech companies and cancer drugs make up the largest single part of biopharmaceutical research and development.

The role of innovation

Small, super-innovative biotech enterprises are important drivers for the whole drug discovery and manufacturing industry. Acquiring such a company means getting specific know-how and promising drugs in the pipeline (without having to self-invest into sophisticated R&D). Thus, these companies are often targets of large pharmaceutical companies for acquisitions or at least some form of alliance. A very good example is what we currently see in the development of COVID-19 vaccines where small and mid-sized biotech firms or research institutes are the vanguard of progress, sometimes being partnered with established big pharma companies (e.g. Pfizer with BionTech, AstraZeneca with Oxford).

Key figures

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U.S. companies

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Interesting statistics

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Medical biotech industry

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Medical biotechnology - Statistics & Facts

In general, biotechnology is defined as the use of biological systems or living organisms for the development of its products. The same is true for biopharmaceuticals, also known as biotech drugs, or biologics. Biotech drugs are also called large molecule drugs because they have a large, complex molecular structure and are more difficult and expensive to produce. In contrast to that, small molecule drugs are chemical-pharmaceutical products with less complexity. While these ‘classic’ pharmaceuticals still make up around 90 percent of all drugs available on the global market, biopharmaceuticals already generate nearly one third of global drug sales. Several smaller biotech companies, previously only known to industry insiders, have become apparent lately through their involvement in the search for a COVID-19 vaccine.

Biotech’s regional concentration

The key regions for the biotech industry are the United States and Europe where most of the nearly 290 billion U.S. dollars of global biotech drug sales are generated. California (Bay Area, L.A., San Diego) and the U.S. Northeast (Boston area, New York, New Jersey) are global leading hubs based on the concentration of life sciences/biotech knowledge. Many of the world’s largest biotech companies originate from these areas as well as many of the most promising startups.

Top companies Amgen and Roche

Amgen, based in Thousand Oaks, California, is the world's largest pure-play biopharmaceutical company by revenue. However, since the acquisition of U.S.-based Genentech in 2009, Swiss pharmaceutical company Roche has the highest biotech revenues worldwide. It is not easy to define a company as biotech or classic pharma since most of the pharma giants already have a mixed portfolio of products with biotech-derived drugs making up an increasing share of total revenues.

Biologics already dominate

When it comes to top-selling drugs, biologics already have a predominant position compared to classic, small molecule drugs. Most of the world’s leading drugs based on revenue are biotech-derived. Illinois-based company AbbVie is the manufacturer of the currently best-selling biotech drug worldwide - Humira. Another biopharmaceutical, Merck’s cancer drug Keytruda, is expected to take over the leading position and to become the most-revenue-generating drug ever by 2026. Oncology is extremely prominent among biotech companies and cancer drugs make up the largest single part of biopharmaceutical research and development.

The role of innovation

Small, super-innovative biotech enterprises are important drivers for the whole drug discovery and manufacturing industry. Acquiring such a company means getting specific know-how and promising drugs in the pipeline (without having to self-invest into sophisticated R&D). Thus, these companies are often targets of large pharmaceutical companies for acquisitions or at least some form of alliance. A very good example is what we currently see in the development of COVID-19 vaccines where small and mid-sized biotech firms or research institutes are the vanguard of progress, sometimes being partnered with established big pharma companies (e.g. Pfizer with BionTech, AstraZeneca with Oxford).

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